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KMID : 0365819880280020123
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Journal of Pusan Medical College
1988 Volume.28 No. 2 p.123 ~ p.137
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Experimental Study on the Effect of Magnitude of Bipolar Coagulation and Time Course in Brain
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Abstract
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The bipolar coagulation lesions were generated by various magnitude (System 5000 ES Generator Unit) in the brain of rabbit. The microscopic features, extent of lesions and time course with Evans blue and Hematoxyhn-eosin stain were observed.
The results were as follows
1. The histologic findings were similar regardless of the magnitude of electric coagulation and time. Microscopically, the lesions were characterized by ground substance depigmentation, vacuolization and neuronal damage with pylmotic nuclei and loss of detail. In section stained with Evans blue, the lesion was demarcated with blue-green discoloration of the parenchyma and superficial cortical necrosis was observed at coagulation site.
2. Radius of cut surface of lateral margin of lesion on cortical surface was proportionally increased with the increase of magnitude of electric coagulation and time.
3. Distance between coagulation site and center of lateral margin of lesion on cortical surface was proportionally increased with the increase of magnitude of electric coagulation and time. Distance between center of lateral margin of lesion on cortical surface and deepest lesion point with Evans blue was longer than H-E stain and it was proportionally increased with the increase of magnitude of electric coagulation and time.
Distance between coagulation site and deepest lesion point was increased with the increase of magnitude of electric coagulation and time.
4. Direct distance between coagulation site and lateral margin of lesion on cortical surface was proportionally increased with the increase of magnitude of electric coagulation and time.
5. Direct distance between lateral margin of lesion on cortical surface and center of deepest lesion point was pro portionally increased with the increase of magnitude of electric coagulation and time.
6. Distance of cortical surface between coagulation site and lateral margin of lesion on cortit- surface was proportionally increased with the increase of magnitude of electric coagulation and time.
7. Cut surface of corona] lesion with Evans blue was larger as 2 times than H-E stain. The surface was widened with the increase of magnitude of coagulation and time.
These results suggest that the neural damage resulting from electric coagulation may be due to the blood-brain barrier dysfunction of thermal origin. The size of lesions were increased with the increase of magnitude of electric coagulation and time.
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